Biochem/physiol Actions

ED50 = 2.6 µM for Aβx-40

Reversible: yes

Product does not compete with ATP.

Primary TargetAβ_x-40

Cell permeable: yes

General description

A cell-permeable, reversible inhibitor of γ-secretase. Inhibits the release of Aβ_x-40 (ED₅₀ = 2.6 µM) and Aβ_x-42 (ED₅₀ = 2.7 µM) in HEK293 cells stably transfected with Amyloid Precursor Protein Swedish mutants.

A cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβ_x-40 (ED₅₀ = 2.6 µM) and Aβ_x-42 (ED₅₀ = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Green, K.N., et al. 2002. J. Physiol.541.3, 1013.Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sequence

2-Naphthoyl-Val-Phe-CHO

Warning

Toxicity: Standard Handling (A)